ABSTRACT
Pseudomonas aeruginosa was diagnosed in association with human persistent pyuria. It was noted among immunoreactive and immunocompromized patients. The test patient showed high; total serum protein, total circulating globulin and high mucosal globulin concentrations than those of normal subjects. The immunoglobulin concentration for the classes IgG IgM and IgA were higher than those normal subjects. The albumin - globulin ratio was lower than those of normal subjects. Circulating anti. Pseudomans aeruginosa specific agglutinins were of titer median value of 400 mucosal specific agglutinins, however, they were with median titer values of 40. in immunreactive patients. While they were of titer median values of 240, and 40 in the immunocomproruized patients. Likewise significant migration inhibition index LIF were noted in peripheral blood leukocytes and Mucosul leucocytes in immunreactive and nonsignificant in the immunocompromized patient. This can be due to the presence of an immunodominant T dependent and/or T independent epitopes
Subject(s)
Humans , Male , Female , Pyuria/microbiology , Pseudomonas aeruginosa/immunology , Immunocompromised Host , Blood Proteins , Serum Globulins , Immunoglobulin G , Immunoglobulin M , Immunoglobulin A , Serum Albumin , AgglutininsABSTRACT
Background. Bacteriuria = 10 to fifth CFU/ml is evidence of urinary tract infection in the absence of associated signs or symptoms. The presence of pyuria with asymptomatic bacteriuria established the response of elderly women against microorganisms capable of causing invasiveness or tissue injury of the urinary tract. Methods. The association between bacteriuria and pyuria was determined in 178 elderly, ambulatory women without symptoms of urinary tract infection in seven nursing homes. Urine culture results were subsequently analyzed in conjunction with absolute leukocyte count in urine. In this cross-sectional study, asymptomatic bacteriuria in elderly women was classified with and without pyuria. Results. The prevalence of asymptomatic bacteriuria was found in 44 (24.7 percent) elderly women. The presence of pyuria had a sensitivity of 63.6 percent for bacteriuria and a specificity of 91 percent. The positive predictive value for the presence of pyuria predicting those with bacteriuria was 70 percent, and the negative predictive value for the absence of pyuria predicting those without bacteriuria was 88.4 percent. Escherichia coli was the most common organism isolated in 81.8 percent of the women. Conclusions. bacteriuria = 10 to fifth CFU/ml associated with pyuria was detected in 77 percent of elderly women with asymptomatic urinary tract infections bacteriuria of < 10 to fifth CFU/ml with pyuria proves less sensitive as an indicator of urinary tract infection. Elderly women with pyuria but without bacteriuria should be studied for other causes of urinary tractinflammation